DEPARTMENT 1

Animal Structure and Function

Anatomy, Histology and Embryology

  1. Connectivity in the central and the peripheral nervous system studied with tracing techniques.
  2. Monoaminergic, cholinergic and peptidergic systems in the developing and mature central nervous system studied with immunocytochemical methods.
  3. Interactions between chemically defined systems in the developing and mature central nervous system of the normal and experimentally manipulated animals.
  4. Embryonic and postnatal development of the central nervous system of mouse, rat and chicken.
  5. Apoptosis in normal and experimentally manipulated animals.
  6. Vascular network of the developing and the adult brain.
  7. Development of animal models for the study of neuropathies associated with different diseases.
  8. Distribution of primary afferent neurons in the spinal cord in experimental animals.
  9. Neural networks associated with the milk-ejection reflex in the sheep.

Biochemistry – Toxicology

  1. Study of the expression of cancer-related genes in animal models of neoplasmatogenesis.
  2. The use of Molecular Biology techniques in the diagnosis of genetic and infectious diseases of domestic and reproductive animals.
  3. Biochemical (aetio)pathology of neuropathies.
  4. Biochemical and toxicological aspects of the neuronal cytoskeleton.
  5. The developmental neurotoxicity of organophosphate pesticides and other environmental chemicals.
  6. The use of cell cultures and other alternative methods in Biochemistry and Toxicology.

Physiology

  1. Research on the physiological role of the plasminogen activator/plasmin system in the cardiovascular, reproductive and other systems. In vivo studies on the effects of various physiological factors (hormones, vitamins, etc.) on the activity of these proteolytic enzymes and their inhibitors. Physiological significance of these effects.
  2. In vivo and ex vivo studies with application of Molecular Biology techniques on the modulation of the plasminogen activator/plasmin system by the above-mentioned factors, as well as by pro-oxidants and antioxidants, and its potential role in apoptosis. Exploration of the role of plasminogen activators on the reproductive system (mainly on epididymis) and on sperm physiology.
  3. Research on the physiological role of acrosin, an important proteolytic enzyme of the acrosome.
  4. Studies on in vitro maturation and fertilization of bovine oocytes.

Pharmacology

  1. Pharmacodynamic studies (mechanism of action and interactions) of several drugs on isolated tissue preparations.
  2. Study of pharmacokinetics, bioequivalence and metabolism of veterinary medical products.
  3. Mobilization of metal ions, due to the administration of several drugs used for long term treatments.