Animal Structure and Function
Anatomy, Histology and Embryology
- Connectivity in the central and the peripheral nervous system studied with tracing techniques.
- Monoaminergic, cholinergic and peptidergic systems in the developing and mature central nervous system studied with immunocytochemical methods.
- Interactions between chemically defined systems in the developing and mature central nervous system of the normal and experimentally manipulated animals.
- Embryonic and postnatal development of the central nervous system of mouse, rat and chicken.
- Apoptosis in normal and experimentally manipulated animals.
- Vascular network of the developing and the adult brain.
- Development of animal models for the study of neuropathies associated with different diseases.
- Distribution of primary afferent neurons in the spinal cord in experimental animals.
- Neural networks associated with the milk-ejection reflex in the sheep.
PhD Students
- Siasios Athanasios, DVM
«Comparative Anatomical Study of the Adrenal Glands of the Mammals»
PostGraduate Research
- Bekiari Chryssa, DVM
«Study of neurogenesis along the dentate gyrus of the adult brain hippocampal formation»
Biochemistry – Toxicology
- Study of the molecular mechanism of carcinogenesis in animal models.
- Biochemical and toxicological aspects of the neuronal cytoskeleton.
- The developmental neurotoxicity of organophosphate pesticides and other environmental chemicals.
- The use of cell cultures and other alternative methods in Biochemistry and Toxicology.
- Regulatory and mechanistic toxicology
Laboratory of Animal Physiology
Research area of interest
- Physiological role of the “plasminogen activator/plasmin” system in the cardiovascular, reproductive and other biological systems. Physiological factors (hormones, vitamins, etc.) influencing the activity of these proteolytic enzymes and their inhibitors.
- In vivo studies of natural antioxidants on lipid peroxidase, apoptosis and redox status of tissues and organs.
- In vivo and in vitro studies on the effect of different physiological factors (hormones, vitamins, etc.) on specific proteases in spermatozoa and seminal plasma. Exploration of the role of plasminogen activators on the reproductive system especially on sperm and oocyte physiology.
- Studies of antioxidant’s effect on fertilization capacity of bovine sperm and In Vitro Embryo Production.
- The use of primary cell cultures and other alternative methods in Physiology and physiopathology of tissue and body systems.
Funding for Research Projects
– “The effect of melatonin on acrosin activity in spermatozoa of the ram”. Funded by the Scientific Committee of the Technological Educational Institute of Larissa, Greece.
– “Effect of gossypol on plasminogen activator/plasmin system in ovine spermatozoa”. Funded by the Scientific Committee of the Research Committee of University of Thessaly, Greece.
– “The effect of plasmin on the induction of acrosome reaction in bull spermatozoa, in vitro” Funded by the Scientific Committee of the Research Committee of University of Thessaly, Greece.
– “Effect of Vitamin A on Plasminogen Activator Activity, Capacitation and Acrosome Reaction of Spermatozoa, and in vitro Fertilization in the Ram”. Funded by the Scientific Committee of the Technological Educational Institute of Epirus, Greece.
– “Effect of supplementation of oregano and rosemary, natural sources of antioxidants, on lipid peroxidation and fibrinolytic activity of the body. Study on rats after causing an experimental oxidative stress”. Co- Funded by European Union-European Social Fund and National Resources, EPEAEK II, Pythagoras I, Greece.
– “Modifications of surface glycoproteins of bovine spermatozoa mediated by oviductal fluid”. Funded by Fulbright Program.
– “Antioxidant effect of crocin, a carotenoid constituent of saffron (Crocus sativus L.) on some parameters of in vitro embryo production”. Funded by the Research Committee of Aristotle University of Thessaloniki, Greece.
– “In vivo preclinical safety assessment of cell therapy immunomodulatory progenitor cells (iMPs) administration in SCID mice. Funded by the Cell Therapy Ltd, Cardiff, England.
– “The effect of polyphenols on the concentration of blood glucose, Plasminogen activator inhibitor-1 and on various antioxidant’s gene expression in diabetic rats”. Funded by the Research Committee of Aristotle University of Thessaloniki, Greece.
– “The effect of saffron carotenoids on fibrinolysis /homeostasis”. Funded by the Public Welfare Institution: Ch. Kerameos of Thessaloniki, Greece.
Research Activity
Post-doc research
- Vasiliki Sapanidou, DVM, PhD
“The presence of crocin in the freezing medium and its effect on bovine sperm characteristics”. Supervisor: Professor Maria Tsantarliotou
Pharmacology
- Pharmacokinetics – Bioequivalence studies
- Pharmacodynamics
- Pharmacokinetic/pharmacodynamic correlation
- Chemical analysis – High Performance Liquid Chromatography (HPLC)
- Antimicrobial Resistance